Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
نویسندگان
چکیده
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2015